Light chain deposition disease without proteinuria
نویسندگان
چکیده
منابع مشابه
Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist.
BACKGROUND Renal involvement in light chain (LC) deposition disease (LCDD) is typically characterized by nodular glomerulosclerosis and nephrotic range proteinuria. Rare cases of LCDD without glomerular symptoms have been reported, but clinical and pathological characteristics of this entity remain poorly described. METHODS This multi-centre retrospective study included 14 patients with biops...
متن کاملLight chain disease and massive proteinuria.
We describe the case of a 64-year-old man with lambda type light chain disease, in whom panhypogammaglobulinemia was associated with anemia, massive Bence Jones proteinuria (24.6 g/L), and renal failure. Lambda type light chains were present in the serum.
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BACKGROUND Conventional chemotherapy for myeloma yield unsatisfactory results in light and/or heavy chain deposition disease [(H)CDD] Because of the well-established dose-response effect of high dose melphalan in multiple myeloma, aiming to dramatically reduce the pathogenic monoclonal immunoglobulin (MIg) level, high dose therapy is a tempting alternative approach. METHODS We treated 11 youn...
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Light chain deposition disease (LCDD) is a rare systemic disorder in which monoclonal light chains are abnormally secreted due to clonal proliferation of plasma cells and get deposited in various organs; the kidneys being the common one to be affected leading to renal failure. Advocated therapeutic options include chemotherapy with alkylating agents and steroids, High-Dose Melphalan (HDM) with ...
متن کاملLight chain deposition disease; there are reasons for confusion
Implication for health policy/practice/research/medical education: Congo red negative nodular deposition of an amorphous, eosinophilic material is the most common pathologic finding in light chain deposition disease in light microscopy. The nodules are a mixture of light chain and mesangial protein and the picture is reminiscent of diabetic nephropathy. Immunoflurescent microscopy usually demon...
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ژورنال
عنوان ژورنال: eJHaem
سال: 2020
ISSN: 2688-6146,2688-6146
DOI: 10.1002/jha2.102